adenomatous polyposis coli protein (protein APC, APC, DP25)

Function

• tumor suppressor
• promotes rapid degradation of CTNNB1
• participates in Wnt signaling
• APC activity is correlated with its phosphorylation state
• interacts with DIAPH1 & DIAPH2
• interacts with PDZ domains of DLG1 & DLG3
• associates with catenins, affects downregulation of beta-catenin
• binds axin
• interacts with the N-terminus of ARHGEF4, & the C-terminus of MAPRE1, MAPRE2 & MAPRE3
• found in a complex consisting of ARHGEF4, APC & CTNNB1
• interacts with APC2
• phosphorylated by GSK3B

Structure

• forms homooligomers
• belongs to the adenomatous polyposis coli (APC) family
• contains 7 ARM repeats

Alternative splicing

named isoforms=2

Expression

expressed in a variety of tissues

Pathology

• defects in APC are a cause of
  • familial adenomatous polyposis, including Gardner syndrome (autosomal recessive)
  • hereditary desmoid disease (autosomal dominant)
  • medulloblastoma
  • Turcot syndrome

More general terms

• anti-oncoprotein (tumor suppressor protein)
• phosphoprotein

Additional terms

• adenomatous polyposis coli protein 2 (adenomatous polyposis coli protein-like, APC2, APCL)

Database

• UniProt: http://www.uniprot.org/uniprot/P25054.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:324
• OMIM: https://mirror.omim.org/entry/135290
• OMIM: https://mirror.omim.org/entry/155255
• OMIM: https://mirror.omim.org/entry/175100
• OMIM: https://mirror.omim.org/entry/276300
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=324