microtubule-associated protein RP/EB family member 3; end-binding protein 3; EB3; EB1 protein family member 3 (EBF3, RP3, MAPRE3)

Function

• microtubule polymerization & spindle function by stabilizing microtubules & anchoring them at centrosomes
• role in cell migration (putative)
• interacts with DCTN1
• binds to the C-terminal domain of APC
• binds monomeric & polymerized tubulin
• two functionally independent domains
  • N-terminal domain forms an hydrophobic cleft involved in microtubule binding
  • C-terminal involved in formation of mutually exclusive complexes with APC & DCTN1

Structure

• belongs to the MAPRE family
• contains 1 CH domain (calponin-homology domain)
  • contains 1 EB1 C-terminal domain

Compartment

cytoplasm, associated with the microtubule network

Alternative splicing

named isoforms=2

Expression

expressed in brain & muscle

More general terms

• microtubule-associated protein (MAP)

Database

• OMIM: https://mirror.omim.org/entry/605788
• UniProt: http://www.uniprot.org/uniprot/Q9UPY8.html