dynactin-1 (dynactin p150, p150-glued, 150 kD dynein-associated polypeptide, DP-150, DAP-150, p135, DCTN1)

Function

• subunit of dynactin
• interacts with C-terminus of MAPRE1, MAPRE2 & MAPRE3
• phosphorylated

Structure

• belongs to the dynactin 150 kD subunit family
• contains 1 CAP-gly domain

Compartment

cytoplasm, cytoplasm, cytoskeleton

Alternative splicing

named isoforms=2

Expression

brain

Pathology

• defects in DCTN1 are the cause of progressive lower motor neuron disease

More general terms

• protein subunit
• phosphoprotein

Component of

• dynactin

Database

• UniProt: http://www.uniprot.org/uniprot/Q14203.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1639
• OMIM: https://mirror.omim.org/entry/601143
• OMIM: https://mirror.omim.org/entry/607641