microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2, end-binding protein 2, EB2, MAPRE2, RP1)

Function

• role in microtubule polymerization & spindle function by stabilizing microtubules & anchoring them at centrosomes (putative)
• role in cell migration (putative)
• interacts with DCTN1
• binds to C-terminal domain of APC
• binds monomeric & polymerized tubulin

Structure

• composed of 2 functionally independent domains
  • N-terminal domain forms an hydrophobic cleft involved in microtubule binding
  • C-terminal domain is involved in formation of mutually exclusive complexes with APC & DCTN1
• belongs to the MAPRE family
• contains 1 CH domain (calponin-homology domain)
  • contains 1 EB1 C-terminal domain

Compartment

• cytoplasm
• associated with microtubule network
• accumulates at plus end of microtubules

Alternative splicing

named isoforms=2

Expression

• up-regulated in activated B-cells & T-lymphocytes

Pathology

• expressed in different tumor cell lines

More general terms

• microtubule-associated protein (MAP)
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/605789
• UniProt: http://www.uniprot.org/uniprot/Q15555.html