adenomatous polyposis coli protein 2 (adenomatous polyposis coli protein-like, APC2, APCL)

Function

• promotes rapid degradation of CTNNB1
• may function as tumor suppressor.
• may function in Wnt signaling
• interacts with PSRC1 (putative)
• interacts with APC, CTNNB1, MAPRE1, MAPRE3, TP53BP2 & possibly with AXIN2

Structure

• belongs to the adenomatous polyposis coli (APC) family
• contains 6 ARM repeats

Compartment

• cytoplasm
• Golgi (cytoplasmic side)
• cell membrane (cytoplasmic side)
• associated with actin filaments & the microtubule network

Alternative splicing

named isoforms=3

Expression

• widely expressed (at protein level)
• specifically expressed in the CNS
• expressed in fetal brain

More general terms

• anti-oncoprotein (tumor suppressor protein)
• cytoskeletal protein

Additional terms

• adenomatous polyposis coli protein (protein APC, APC, DP25)

Database

• UniProt: http://www.uniprot.org/uniprot/O95996.html