proline/serine-rich coiled coil protein 1 (PSRC1 DDA3 FP3214)

Function

• required for progression through mitosis
• required for congress of chromosomes at the metaphase plate
• role in chromosomal segregation during anaphase
• role in regulation of mitotic spindle dynamics
  • increases turnover of microtubules on metaphase spindles
  • contributes to tgeneration of normal tension across sister kinetochores
  • recruits KIF2A & ANKRD53 to the mitotic spindle & spindle pole
• may participate in p53-regulated growth suppression

Compartment

cytoplasm

Alternative splicing

named isoforms=4 Name=D

More general terms

• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6PGN9.html