kinesin heavy chain 2A (Kif2A, kinesin family protein 2, HK2, KIF2, KNS2)

Function

• plus end-directed microtubule-dependent motor required for normal brain development
• may regulate microtubule dynamics during axonal growth
• implicated in formation of bipolar mitotic spindles
• has microtubule depolymerization activity

Structure

• belongs to the kinesin-like protein family, MCAK/KIF2 subfamily
• contains 1 kinesin-motor domain
• phosphorylated on Ser-579 (putative)

Compartment

• cytoplasm (putative)
• centrosome

Alternative splicing

named isoforms=4

Pathology

• HeLa cells lacking KIF2A show asymmetric or monopolar mitotic spindles
• osteosarcoma cells (U2OS) lacking KIF2A or KIF2B show disorganised or monopolar mitotic spindles Kif2 gene cloned from follicular B-cell lymphoma cells treated with synthetic retinoid HPR. (see OMIM :accession 602591)

More general terms

• kinesin heavy (alpha) chain
• kinesin family protein
• phosphoprotein

Additional terms

• kinesin-2

Database

• OMIM: https://mirror.omim.org/entry/602591
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3796
• UniProt: http://www.uniprot.org/uniprot/O00139.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3796