haptoglobin-related protein (HPR)

Structure

• belongs to the peptidase S1 family
• contains 1 peptidase S1 domain
• contains 1 Sushi (CCP/SCR) domain

Compartment

secreted (putative)

Alternative splicing

named isoforms=2

Expression

• in adult liver, HPR mRNA is expressed at the lower limit of detection
• no HPR mRNA can be detected in fetal liver
• expressed in hepatoma G2 & leukemia molt-4 cell lines

Notes

• although homologous to serine proteases, it has lost all essential catalytic residues & has no enzymatic activity

More general terms

• alpha 2 globulin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3250
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3250
• OMIM: https://mirror.omim.org/entry/140210
• UniProt: http://www.uniprot.org/uniprot/P00739.html