kinesin-like 6 protein (kinesin-like protein KIF2C, mitotic centromere-associated kinesin, kinesin-like protein 6, MCAK, KIF2C, KNSL6)

Function

• present throughout the cell cycle
• associates with centromeres at early prophase remains associated with centromere until after telophase (putative)
• interacts with CENPH
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the kinesin-like protein family, MCAK/KIF2 subfamily
• contains 1 kinesin-motor domain

Compartment

• cytoplasm, cytoskeleton (putative)
• nucleus (putative), centromere

Alternative splicing

named isoforms=2

Expression

• present throughout the cell cycle
• expressed in tissues containing dividing cells
• expressed at high levels in thymus & testis, at low levels in small intestine, mucosal lining of colon, & placenta, & at very low levels in spleen & ovary
• expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas

More general terms

• kinesin family protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/604538
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1100
• UniProt: http://www.uniprot.org/uniprot/Q99661.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11004