NDC80 complex

Function

• required for chromosome segregation & spindle checkpoint activity
• required for kinetochore integrity & organization of stable microtubule binding sites in the outer plate of the kinetochore

Structure

• consists of: KNTC2/HEC1, CDCA1, SPBC24, SPBC25
• elongated rod-like structure with globular domains at either end

More general terms

• molecular complex

Database

• UniProt: http://www.uniprot.org/uniprot/O14777.html