kinetochore protein Hec1 (HsHec1, kinetochore-associated protein 2, highly expressed in cancer protein, retinoblastoma-associated protein HEC, KNTC2, HEC, HEC1)

Function

• acts as a component of the essential kinetochore-associated NDC80 complex
• kinetochore integrity & organization of stable microtubule binding sites in outer plate of kinetochore
• interacts with NEK2 & ZWINT specifically during mitosis
• interacts with CENPH & MIS12
• interacts with AURKB, PSMC2, PSMC5, SMC1L1 (putative)
• interacts with RB1 during G2 phase & mitosis (putative)
• phosphorylation begins in S phase of cell cycle & peaks in mitosis
• phosphorylated by NEK2
• may also be phosphorylated by AURKA & AURKB

Compartment

• nucleus, kinetochore
• localizes to kinetochores from late prophase to anaphase
• localizes specifically to the outer plate of kinetochore

Expression

• peaks in mitosis

More general terms

• kinetochore protein
• phosphoprotein

Component of

• NDC80 complex

Database

• OMIM: https://mirror.omim.org/entry/607272
• UniProt: http://www.uniprot.org/uniprot/O14777.html