serine/threonine protein kinase 6; Aurora kinase A; Aurora/IPL1-related kinase 1; ARK-1; Aurora-related kinase 1; hARK1; breast tumor-amplified kinase; serine/threonine protein kinase 15; serine/threonine protein kinase aurora-A (AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6)

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Function

role in regulation of cell cycle progression
required for normal mitosis
associates with centrosome & spindle microtubules during mitosis & functions in centrosome maturation, spindle assembly, maintenance of spindle bipolarity, centrosome separation & mitotic checkpoint control
phosphorylates numerous target proteins, including ARHGEF2, BRCA1, KIF2A, NDEL1, PARD3, PLK1 & BORA
regulates KIF2A tubulin depolymerase activity (putative)
required for normal axon formation
role in microtubule remodeling during neurite extension
important for microtubule formation &/or stabilization
activated by phosphorylation at Thr-288; this brings about a conformational change in the activation segment
phosphorylation at Thr-288 varies during the cell cycle & is highest during M phase
autophosphorylated at Thr-288 upon TPX2 binding
phosphorylated upon DNA damage, probably by ATM or ATR
ubiquitinated by CHFR, leading to its degradation by the proteasome (putative)
ubiquitinated by the anaphase-promoting complex (APC), leading to its degradation by the proteasome
interacts with TPX2
interacts with TACC1 & CPEB1
interacts with its substrates BORA, BRCA1, KIF2A, PARD3 & ARHGEF2
interaction with BORA promotes phosphorylation of PLK1

belongs to the protein kinase superfamily, Ser/Thr protein kinase family, Aurora subfamily
contains 1 protein kinase domain

highly expressed in testis
weakly expressed in skeletal muscle, thymus & spleen
expression is cell-cycle regulated, low in G1/S, accumulates during G2/M, & decreases rapidly after
highly expressed in tumor cell lines