ZW10 interactor; ZW10-interacting protein 1; Zwint-1 (ZWINT)

Function

• component of the MIS12 complex
  • interacts with MIS12
• required to target ZW10 to the kinetochore at prometaphase
• interacts with KNTC2 subunit of the NDC80 complex specifically during mitosis
• interacts with CASC5, CETN3, DSN1 & PMF1

Compartment

• nucleus, kinetochore
• localizes to kinetochores from late prophase to anaphase

More general terms

• nuclear protein
• human longevity protein

Additional terms

• centromere/kinetochore protein zw10 homolog (ZW10)
• M-phase phosphoprotein 5 (antisense ZW10 interactor, ZWINTAS)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11130
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11130
• OMIM: https://mirror.omim.org/entry/609177
• UniProt: http://www.uniprot.org/uniprot/O95229.html