polyamine-modulated factor 1 (PMF-1, PMF1)

Function

• component of MIS12 complex
• may act as a cotranscription partner of NFE2L2 with role in regulation of polyamine-induced transcription of SSAT
• interacts with COPS7A
• interacts via its coiled-coil domain with the leucine-zipper domain of NFE2L2
• interaction with NFE2L2 is required for the transcriptional regulation of SSAT

Compartment

nucleus, kinetochore

Alternative splicing

named isoforms=5

Expression

• expression in heart & skeletal muscle > kidney & liver -induced by polyamine analogs in analog-sensitive H157 cells

More general terms

• kinetochore protein
• nuclear protein

Additional terms

• polyamine

Database

• UniProt: http://www.uniprot.org/uniprot/Q6P1K2.html