diamine acetyltransferase; spermidine/spermine N1-acetyltransferase; putrecine acetyltransferase; polyamine N-acetyltransferase 1 (SSAT, SSAT-1, SAT1, SAT)

Function

• catalyzes the acetylation of polyamines
• substrate specificity: norspermidine = spermidine >> spermine > N1-acetylspermine > putrescine
• highly regulated enzyme
• allows a fine attenuation of the intracellular concentration of polyamines
• also involved in the regulation of polyamine transport out of cells
• amine & polyamine degradation; putrescine degradation
• N-acetylputrescine from putrescine: step 1/1
• acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N1- & N(8)-acetylspermidine), spermine, N1-acetylspermidine & N(8)-acetylspermidine

acetyl-CoA + an alkane-alpha,omega-diamine
               <-->
CoA + an N-acetyldiamine

Structure

• homotetramer
• belongs to the acetyltransferase family
• contains 1 N-acetyltransferase domain

Compartment

cytoplasm

Pathology

• defects in SAT1 may be the cause of keratosis follicularis spinulosa decalvan

More general terms

• acetyltransferase

Database

• UniProt: http://www.uniprot.org/uniprot/P21673.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6303
• OMIM: https://mirror.omim.org/entry/308800
• OMIM: https://mirror.omim.org/entry/313020