nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; nuclear factor, erythroid derived 2, like 2; HEBP1 (NFE2L2 NRF2)

Function

• transcription activator
• binds to & regulates transcription through the antioxidant response elements (ARE) in promoter regions of target genes
• role in coordinated up-regulation of genes in response to oxidative stress
• role in transcriptional activation of beta-globin cluster genes by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region
• may bind to the ARE as a heterodimer with maf protein
• may bind DNA with an unknown protein
• interacts with KEAP1 (cytoplasmic inhibitor)
• interacts via its leucine-zipper domain with the coiled-coil domain of PMF1
• phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NRF2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus (putative)
• phosphorylation of NFE2L2 by member of the MAP kinase family appears to prevent degradation by the 26S proteasome

Structure

• acidic activation domain in the N-terminus
• DNA-binding domain in the C-terminus
• belongs to the bZIP family, CNC subfamily
• contains 1 bZIP domain

Compartment

• cytoplasm, nucleus
• cytosolic under unstressed conditions
• translocates into the nucleus upon induction by electrophilic agents

Alternative splicing

named isoforms=2

Expression

• widely expressed
• highest expression in adult muscle, kidney, lung, liver & in fetal muscle

More general terms

• DNA-binding protein
• transcription factor (TF)
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4780
• OMIM: https://mirror.omim.org/entry/600492
• UniProt: http://www.uniprot.org/uniprot/Q16236.html