solute carrier family 8 member 1; Na+/Ca+2 exchanger 1; Na+/Ca+2-exchange protein 1 (SLC8A1, CNC, NCX1)

Function

• rapidly transports Ca+2 during excitation-contraction coupling
• Ca+2 is extruded from the cell during relaxation so as to prevent overloading of intracellular stores by ATP

Structure

• belongs to the Na+/K+/Ca+2 exchanger family, SLC8 subfamily
• contains 2 calx-beta domains

Compartment

cell membrane; multi-pass membrane protein

Alternative splicing

named isoforms=4

Expression

• expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta & lung

More general terms

• transmembrane 11e protein
• glycoprotein
• Ca+2 binding protein
• solute carrier family 8 (SLC8, SLC8A, Na+/Ca+2 exchanger)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6546
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6546
• OMIM: https://mirror.omim.org/entry/182305
• UniProt: http://www.uniprot.org/uniprot/P32418.html