hemoglobin beta chain (beta globin, HBB)
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Function
- beta subunit of hemoglobin
- binds 2,3-bisphospoglycerate regulating affinity of hemoglobin for oxygen
- one molecule of 2,3-bisphospoglycerate can bind to two beta chains per hemoglobin tetramer
- LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure
- S-nitrosylated a nitric oxide group is first bound to Fe+2 & then transferred to Cys-94 to allow capture of O2
- acetylated on Lys-60, Lys-83 & Lys-145 upon aspirin exposure
- glucose reacts non-enzymatically with the N-terminus of the beta chain to form a stable ketoamine linkage this takes place slowly & continuously throughout the 120-day life span of the red blood cell the rate of glycation is increased in patients with diabetes mellitus (see hemoglobin A1c)
Structure
- belongs to the globin family
- MASS SPECTROMETRY: mass=1310; method=FAB; Range=33-42
Expression
Pathology
- defects in HBB may be a cause of Heinz body anemias
- defects in HBB are the cause of beta-thalassemia
- dominant beta-thalassemia inclusion body type
- defects in HBB are the cause of sickle cell anemia
Laboratory
More general terms
Component of
References
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3043
- ↑ Hbvar; Note: Human hemoglobin variants and thalassemias http://globin.bx.psu.edu/cgi-bin/hbvar/query_vars3?mode=directlink&gene=HBB
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=HBB
- ↑ SHMPD; Singapore human mutation and polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=HBB
- ↑ Wikipedia; hemoglobin entry http://en.wikipedia.org/wiki/hemoglobin
- ↑ UniProt http://www.uniprot.org/uniprot/P68871.html
- ↑ Mass spectroscopy PMID: https://www.ncbi.nlm.nih.gov/pubmed/1575724
Database
- UniProt: http://www.uniprot.org/uniprot/P68871.html
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3043
- OMIM: https://mirror.omim.org/entry/140700
- OMIM: https://mirror.omim.org/entry/141900
- OMIM: https://mirror.omim.org/entry/603902
- OMIM: https://mirror.omim.org/entry/603903
- OMIM: https://mirror.omim.org/entry/604131
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3043