aspirin (Ecotrin, Empirin, Bayer aspirin, Vazalore, ASA)

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Introduction

Acetylsalicylic acid (ASA). Enteric-coated acetylsalicylic acid (ECASA). Tradenames: Ecotrin, Empirin, Bayer.

Indications

* risk for nontrivial bleeding roughly equals benefit in primary prevention of nonfatal myocardial infarction[41]

* benefit exceeds bleeding risk for myocardial infarction, ischemic stroke, & cancer[59]

Contraindications

Caution:

pregnancy category = d

safety in lactation = ?

Benefit/risk

* likely comparing different doses of aspirin or perhaps different patient population with different comorbidities

Dosage

Tabs: 81, 325, 500, 650, 975 mg.

Suppository: 120, 200, 300, 600 mg.

Enteric-coated as effective as plain aspirin in prevention of cardiovascular disease[11]; may be less effective[49]; effectiveness & safety in patients with cardiovascular disease similar[109]

Quick-release form: 325 mg, 500 mg (Bayer)

Vazalore with a special complex within the capsule allows for targeted release of aspirin minimizing direct contact with the stomach.[101]

Pharmacokinetics

elimination via kidney

1/2life = 0.25-0.33 hours

Adverse effects

* GI prophylaxis

Toxicity: (management)

Drug interactions

Mechanism of action

Notes

More general terms

Additional terms

Component of

References

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  22. Prescriber's Letter 15(8): 2008 Can Aspirin 162 mg a Day Keep The Doctor Away? Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=240808&pb=PRL (subscription needed) http://www.prescribersletter.com
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    Prescriber's Letter 17(3): 2010 COMMENTARY: Using Low-Dose Aspirin After a GI Bleed PATIENT HANDOUT: Aspirin and Your Heart PATIENT HANDOUT SPANISH VERSION: La Aspirina y el Corazon GUIDELINES: Recommendations on the Management of Patients with Nonvariceal Upper Gastrointestinal Bleeding Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=260313&pb=PRL (subscription needed) http://www.prescribersletter.com
  35. Prescriber's Letter 17(2): 2010 Aspirin for Primary Prevention Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=260201&pb=PRL (subscription needed) http://www.prescribersletter.com
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