drug interaction(s) of NSAIDs with SSRIs

^[1]^[2]^[3]

Drug interactions

risk of GI bleed, conflicting data
- SSRI used concurrently with NSAIDs increases risk of GI-bleeding 12-fold^[1]
- combining an NSAID with an SSRI did not further elevate the risk of GI bleeding^[2]
- combination of NSAID with SSRI increases risk of upper GI bleed^[3]

↑ ^1.0 ^1.1 Prescriber's Letter 12(7): 2005 Selective Serotonin Reuptake Inhibitors (SSRIs) and Antiplatelet Activity Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=210715&pb=PRL (subscription needed) http://www.prescribersletter.com
↑ ^2.0 ^2.1 Targownik LE et al Selective serotonin reuptake inhibitors are associated with a modest increase in the risk of upper gastrointestinal bleeding. Am J Gastroenterol 2009 Jun; 104:1475. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19491861
↑ ^3.0 ^3.1 Masclee GMC et al. Risk of upper gastrointestinal bleeding from different drug combinations. Gastroenterology 2014 Oct; 147:784 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24937265
Laine L. NSAID-associated gastrointestinal bleeding: Assessing the role of concomitant medications. Gastroenterology 2014 Oct; 147:730. PMID: https://www.ncbi.nlm.nih.gov/pubmed/25167988