drug interaction(s) of direct oral anticoagulants (DOAC) with NSAIDs

^[1]^[2]

Drug interactions

concurent use of NSAIDs with DOAC increases risk of bleeding with DOAC^[1]
concurrent uses of DOAC & aspirin associated with increased bleeding & hospitalizations but similar rate of thrombosis^[2]

↑ ^1.0 ^1.1 Petersen SR, Bonnesen K, Grove EL et al. Bleeding risk using non-steroidal anti-inflammatory drugs with anticoagulants after venous thromboembolism: a nationwide Danish study. Eur Heart J. 2024 Nov 18:ehae736. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39551938 https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehae736/7900494
↑ ^2.0 ^2.1 Schaefer JK, Errickson J, Li Y et al Adverse Events Associated With the Addition of Aspirin to Direct Oral Anticoagulant Therapy Without a Clear Indication. JAMA Intern Med. Published online April 19, 2021 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33871544 https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2778963