aspirin/caffeine/propoxyphene (Darvon Compound)

Introduction

DEA-controlled substance: class 4.

Propoxyphene banned by FDA Feb 2009

Contraindications

pregnancy-category D

safety in lactation -

Dosage

65 mg propoxyphene + 389 mg aspirin + 32.4 mg caffeine.

• 1 tab PO every 4 hours

Pharmacokinetics

elimination: liver > kidney

More general terms

• narcotic combination

Components

• propoxyphene (Darvon, Dolene, Proxagesic, Novopropoxyn)
• aspirin (Ecotrin, Empirin, Bayer aspirin, Vazalore, ASA)
• caffeine (NoDoz, Vivarin)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=656797