caffeine (NoDoz, Vivarin)

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Introduction

Tradenames: NoDoz, Vivarin.

Indications

Dosage

Tabs: 100 & 200 mg.

Pharmacokinetics

elimination via liver

1/2life = 3.5 hours

protein binding = 35 %

Adverse effects

Drug interactions

Laboratory

Mechanism of action

Notes

  • energy drinks may contain significant amounts of caffeine[12]
  • FDA recommends avoiding powdered pure caffeine being marketed directly to consumers[23]

More general terms

Additional terms

Component of

References

  1. ↑ The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. ↑ Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
  3. ↑ 3.0 3.1 Prescriber's Letter 13(3): 2006 Cytochrome P450 drug interactions Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220233&pb=PRL (subscription needed) http://www.prescribersletter.com
  4. ↑ Lindskog et al. Nature 418:774-8, 2002
  5. ↑ 5.0 5.1 Journal Watch 24(11):88, 2004 Savoca MR, Evans CD, Wilson ME, Harshfield GA, Ludwig DA. The association of caffeinated beverages with blood pressure in adolescents. Arch Pediatr Adolesc Med. 2004 May;158(5):473-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15123481
  6. ↑ 6.0 6.1 6.2 Ritchie K, Carriere I, de Mendonca A, Portet F, Dartigues JF, Rouaud O, Barberger-Gateau P, Ancelin ML. The neuroprotective effects of caffeine: a prospective population study (the Three City Study). Neurology. 2007 Aug 7;69(6):536-45. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17679672
  7. ↑ 7.0 7.1 7.2 Lu YP, Nolan B, Lou YR, Peng QY, Wagner GC, Conney AH. Voluntary exercise together with oral caffeine markedly stimulates UVB light-induced apoptosis and decreases tissue fat in SKH-1 mice. Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12936-41. Epub 2007 Jul 30. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17664435
  8. ↑ 8.0 8.1 8.2 Prescriber's Letter 15(3): 2008 Caffeine and the Risk of Miscarriage Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=240309&pb=PRL (subscription needed) http://www.prescribersletter.com
  9. ↑ 9.0 9.1 9.2 Heffernan TP et al. ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: Potential basis for the UV protective effects of caffeine. J Invest Dermatol 2009 Feb 26 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/19242509 <Internet> http://dx.doi.org/10.1038/jid.2008.435
  10. ↑ 10.0 10.1 Committee Opinion No. 462: Moderate Caffeine Consumption During Pregnancy Obstetrics & Gynecology, 2010 116:467-468 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/20664420 <Internet> http://journals.lww.com/greenjournal/Citation/2010/08000/Committee_Opinion_No__462__Moderate_Caffeine.42.aspx
  11. ↑ Mayo Clinic Staff Caffeine content for coffee, tea, soda and more Mayo clinic Health Information http://www.mayoclinic.com/health/caffeine/AN01211
  12. ↑ 12.0 12.1 12.2 Prescriber's Letter 18(1): 2011 Energy Drinks Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=270107&pb=PRL (subscription needed) http://www.prescribersletter.com
  13. ↑ 13.0 13.1 Crowe SF et al The effect of caffeine and stress on auditory hallucinations in a non-clinical sample. Pers Individ Dif 2011 Apr; 50:626 Not indexed in PubMed http://www.sciencedirect.com/science/article/pii/S019188691000591X
    Journal Watch Psychiatry July 11, 2011 Massachusetts Medical Society (Subscription required) http://psychiatry.jwatch.org/cgi/content/full/2011/711/1?q=pfw-featured
  14. ↑ 14.0 14.1 Lucas M et al Coffee, Caffeine, and Risk of Depression Among Women Arch Intern Med. 2011;171(17):1571-1578. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/21949167 <Internet> http://archinte.ama-assn.org/cgi/content/abstract/171/17/1571
    Berkowitz SA Coffee Consumption and Depression Risk Arch Intern Med. 2011;171(17):1578 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/21949168 <Internet> http://archinte.ama-assn.org/cgi/content/extract/171/17/1578
  15. ↑ 15.0 15.1 Salazar-Martinez E et al Ann Intern Med 140:1, 2004 PMID: https://www.ncbi.nlm.nih.gov/pubmed/14706966
  16. ↑ 16.0 16.1 van Dam RM, Hu FB. Coffee consumption and risk of type 2 diabetes: a systematic review. JAMA. 2005 Jul 6;294(1):97-104. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15998896
  17. ↑ 17.0 17.1 Larsson SC et al. Coffee consumption and risk of stroke in women. Stroke 2011 Mar 10 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/21393590 <Internet> http://stroke.ahajournals.org/cgi/content/abstract/STROKEAHA.110.603787v
  18. ↑ 18.0 18.1 18.2 Journal Watch: Massachusetts Medical Society http://www.jwatch.org Sepkowitz KA Energy Drinks and Caffeine-Related Adverse Effects JAMA. 2012, Dec 19 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23330171 <Internet> http://jama.jamanetwork.com/article.aspx?articleid=1487123
  19. ↑ 19.0 19.1 19.2 19.3 19.4 Journal Watch. April 10, 2013 Massachusetts Medical Society http://www.jwatch.org
    Sharwood LN et al. Use of caffeinated substances and risk of crashes in long distance drivers of commercial vehicles: Case-control study. BMJ 2013 Mar 19; 346:f1140. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23511947
  20. ↑ 20.0 20.1 20.2 Deprecated Reference
  21. ↑ 21.0 21.1 Borota D et al Post-study caffeine administration enhances memory consolidation in humans. Nature Neuroscience. Jan 12, 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24413697 <Internet> http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.3623.html
  22. ↑ FDA Safety Alert. July 20, 2014 FDA Consumer Advice on Powdered Pure Caffeine. http://www.fda.gov/Food/RecallsOutbreaksEmergencies/SafetyAlertsAdvisories/ucm405787.htm
  23. ↑ 23.0 23.1 23.2 Hand L Moderate Tea Drinking Tea May Slow CAC Progression, Cut CV Event Risk: MESA. Medscape. Sep 23, 2016 http://www.medscape.com/viewarticle/869038
  24. ↑ 24.0 24.1 Zuchinali P et al. Short-term effects of high-dose caffeine on cardiac arrhythmias in patients with heart failure: A randomized clinical trial. JAMA Intern Med 2016 Oct 17; [e-pub] <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/27749954 <Internet> http://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2569283
  25. ↑ 25.0 25.1 Miller PE, Zhao D, Frazier-Wood AC et al. Associations of coffee, tea, and caffeine intake with coronary artery calcification and cardiovascular events. Am J Med 2017 Feb; 130:188 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/27640739 <Internet> http://www.amjmed.com/article/S0002-9343(16)30925-1/abstract
  26. ↑ 26.0 26.1 26.2 Postuma RB, Anang J, Pelletier A et al. Caffeine as symptomatic treatment for Parkinson disease (Cafe-PD): A randomized trial. Neurology 2017 Sep 27 PMID: https://www.ncbi.nlm.nih.gov/pubmed/28954882
  27. ↑ 27.0 27.1 Papadopoulou E, Botton J, Brantsaeter AL. Maternal caffeine intake during pregnancy and childhood growth and overweight: results from a large Norwegian prospective observational cohort study. BMJ Open, Volume 8, Issue 3. April 2018 http://bmjopen.bmj.com/content/8/3/e018895
  28. ↑ Rothaus C Coffee, Caffeine, and Health NEJM Resident 360. July 22, 2020 https://resident360.nejm.org/clinical-pearls/coffee-caffeine-and-health
  29. ↑ 29.0 29.1 George J Does Caffeine Protect Against Parkinson's? - Benefit seen even for people with Parkinson's genetic risk MedPage Today September 30, 2020 https://www.medpagetoday.com/neurology/parkinsonsdisease/88893
    Crotty GF, Maciuca R, Macklin EA et al Association of caffeine and related analytes with resistance to Parkinson's disease among LRRK2 mutation carriers: A metabolomic study. Neurology 2020. Sept 30. PMID: https://www.ncbi.nlm.nih.gov/pubmed/32999056 https://n.neurology.org/content/early/2020/09/30/WNL.0000000000010863
  30. ↑ 30.0 30.1 Reuter SE, Schultz HB, Ward MB et al The effect of high-dose, short-term caffeine intake on the renal clearance of calcium, sodium and creatinine in healthy adults. Br J Clin Pharmacol 2021. April 14 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33852164 https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bcp.14856
  31. ↑ 31.0 31.1 Mahdavi S, Palatini P, El-Sohem A. CYP1A2 Genetic Variation, Coffee Intake, and Kidney Dysfunction JAMA Netw Open. 2023;6(1):e2247868 PMID: https://www.ncbi.nlm.nih.gov/pubmed/36701157 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800839
  32. ↑ 32.0 32.1 Lu X, Zhu X, Li G, Wu L, Shao L, Fan Y, Pan CW, Wu Y, Borne Y, Ke C. Habitual Coffee, Tea, and Caffeine Consumption, Circulating Metabolites, and the Risk of Cardiometabolic Multimorbidity. J Clin Endocrinol Metab. 2024 Sep 17:dgae552. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39287934
  33. ↑ 33.0 33.1 Spriano P Ready for a Jolt? Caffeine Brings Benefits and Risks Medscape. Oct 11, 2024 https://www.medscape.com/viewarticle/ready-jolt-caffeine-brings-benefits-and-risks-2024a1000ilx

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