protein phosphatase 1 regulatory subunit 1B; DARPP-32; dopamine- & cAMP-regulated neuronal phosphoprotein (PPP1R1B, DARPP32)

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Function

associates & blocks phosphatase-1
dopamine- & cyclic AMP-regulated neuronal phosphoprotein
phosphorylation of Thr-34 is required for activity

Structure

belongs to the protein phosphatase inhibitor 1 family

Compartment

Alternative splicing

named isoforms=2

Expression

highly concentrated in basal ganglia
localized to neurons with D1 dopamine receptors
not associated with particular neurotransmitter type

More general terms

protein phosphatase-1 regulatory subunit

References

↑ UniProt http://www.uniprot.org/uniprot/Q9UD71.html
↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org//genes/PPP1R1BID44096ch17q12.html
↑ ) Armstrong DL Calcium channel regulation by calcineurin, a Ca+2-activated phosphatase in mammalian brain TINS 12(3):117 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2469218
↑ Nestler & Greengard, Basic Neurochemistry 4th ed. p393-4

Database

Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84152
Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84152
OMIM: https://mirror.omim.org/entry/604399
UniProt: http://www.uniprot.org/uniprot/Q9UD71.html

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