dopamine D1A receptor (DRD1)

Function

• dopamine receptor
• activity of this receptor is mediated by G proteins which activate adenylyl cyclase
• interacts with DNAJC14 via its C-terminus
• linked to Gs in medium spiny neurons of striatum

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane
• endoplasmic reticulum membrane
• transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14 (putative)
• dopamine-D1 & D2 receptors colocalize in 60-80% of medium spiny neurons of striatum
• D1 receptors are also present on spines of prefrontal pyramidal cells where it is thought that they modulate input of excitatory synapses during formation of short term or working memory

Expression

• detected in caudate, nucleus accumbens, olfactory tubercle

More general terms

• dopamine receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1812
• Kegg: http://www.genome.jp/dbget-bin/www_bget?son:SO_1
• OMIM: https://mirror.omim.org/entry/126449
• UniProt: http://www.uniprot.org/uniprot/P21728.html