leiomodin-1; Leiomodin, muscle form; 64 kD autoantigen D1; 64 kD autoantigen 1D; 64 kD autoantigen 1D3; thyroid-associated ophthalmopathy autoantigen; smooth muscle leiomodin; SM-Lmod (LMOD1)

Structure

• belongs to the tropomodulin family
• contains 1 WH2 domain

Compartment

cytoplasm, cytoskeleton

Alternative splicing

named isoforms=2

Expression

• smooth muscle (heart, skeletal muscle, colon & small intestine), a subset of striated muscle fibers, & at low level in thyroid

Pathology

• recognized by patients with autoimmune thyroid disease

More general terms

• membrane protein
• antigen

Additional terms

• Hashimoto's thyroiditis; chronic lymphocytic thyroiditis; struma lymphomatosa; lymphadenoid goiter; primary myxedema

Component of

• autoantigen d1/diosmin/hesperidin

Database

• UniProt: http://www.uniprot.org/uniprot/P29536.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=25802
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:25802
• OMIM: https://mirror.omim.org/entry/602715