working memory; mental control
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Introduction
Manipulation of primary memory, synonymous with mental control.
Pathology
- damage to the prefrontal cortex results in impaired working memory
- working memory declines in older adults (60-76 years vs 20-29 years)[2]
- deficits are linked to desynchronization of rhythmic activity between the prefrontal regions that evaluate information & the temporal regions that store it
Diagnostic procedures
- electroencephalography (EEG)
- age-related working-memory deficits are associated with uncoupling of frontotemporal theta (4-8 Hz) & left temporal theta-gamma (> 25 Hz) phase amplitudes on EEG[2]
Management
- targeted high-definition transcranial alternating-current stimulation tuned to individual brain network dynamics for 25 minutes rapidly normalizes cortical-rhythm disruptions, restoring phase synchronization typical of younger adults[2]
More general terms
References
- ↑ Comprehensive Geriatric Assessment, Osterweil et al eds, McGraw Hill, New York, 2000, pg 77
- ↑ 2.0 2.1 2.2 2.3 2.4 Reinhart RMG, Nguyen JA. Working memory revived in older adults by synchronizing rhythmic brain circuits. Nat Neurosci 2019 Apr 8; PMID: https://www.ncbi.nlm.nih.gov/pubmed/30962628 https://www.nature.com/articles/s41593-019-0371-x