phosphatase-1 (PP1)

Function

• protein phosphatase 1 (PP1) is essential for cell division, & participates in the regulation of glycogen metabolism, muscle contractility & protein synthesis
• involved in regulation of ionic conductances & long-term synaptic plasticity
• may play a role in dephosphorylating substrates such as the postsynaptic density-associated CaM kinase 2
• exhibits broad specificity, partly overlapping with protein phosphatase 2A

Inhibition:

• inhibited by calyculin A & akadaic acid

phosphoprotein + H2O = a protein + phosphate Struture:

• PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 & glycogen synthetase kinase 3, & then complexed to one or several targeting or regulatory subunits
• PPP1R12A, PPP1R12B & PPP1R12C mediate binding to myosin
• PPP1R3A, PPP1R3B, PPP1R3C & PPP1R3D mediate binding to glycogen
• PPP1R15A & PPP1R15B mediate binding to EIF2S1

Compartment

• cytoplasm, nucleus, nucleoplasm, nucleolus
• primarily nuclear & largely excluded from the nucleolus
• highly mobile in cells & can be relocalized through interaction with targeting subunits

Notes

• related complexes
  • PTW/PP1 phosphatase complex
  • PPP1R15A-PP1 complex

More general terms

• serine/threonine phosphatase
• phosphoprotein
• nuclear protein
• multisubunit protein

More specific terms

• protein phosphatase 1J; protein phosphatase 2C isoform zeta; PP2C-zeta (PPM1J, PPP2CZ)

Additional terms

• PPP1R15A-PP1 complex
• PTW/PP1 phosphatase complex