serine/threonine protein phosphatase PP1-gamma catalytic subunit; PP-1G; protein phosphatase 1C catalytic subunit (PPP1CC)

Function

• catalytic subunit of protein phosphatase 1 (PP1)
• component of the PTW/PP1 phosphatase complex
• component of the MLL5-L complex
• part of a complex containing PPP1R15B, PP1 & NCK1/2
• interacts with cyanobacterial toxin microcystin; disulfide-linked
• interacts with PPP1R3B & PPP1R7
• isoform gamma-2 interacts with SPZ1 (putative)
• interacts with CDCA2
• interacts with IKFZ1; the interaction targets PPP1CC to pericentromeric heterochromatin,
• dephosphorylates IKAROS, stabilizes it & prevents it from degradation (putative)
• interacts with NOM1 & PPP1R8

Cofactor:

• binds 1 iron ion per subunit
• binds 1 Mn+2 per subunit

a phosphoprotein + H2O = a protein + phosphate

Structure

• belongs to the PPP phosphatase family, PP-1 subfamily

Compartment

• cytoplasm, nucleus, nucleolus, nucleoplasm, nucleus speckle
• chromosome, centromere, kinetochore, cleavage furrow, midbody
• colocalizes with SPZ1 in the nucleus (putative)
• rapidly exchanges between the nucleolar, nucleoplasmic & cytoplasmic compartments
• highly mobile in cells & can be relocalized through interaction with targeting subunits
• in the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles
• shows a dynamic targeting to specific sites throughout the cell cycle
• highly concentrated in nucleoli of interphase cells & localizes at kinetochores early in mitosis
• relocalization to chromosome-containing regions occurs at the transition from early to late anaphase
• accumulates at the cleavage furrow & midbody by telophase

Alternative splicing

named isoforms=2; gamma-1, gamma-2

Notes

• microcystin toxin is bound to Cys-273 through a thioether bond

More general terms

• phosphatase-1 catalytic subunit

Additional terms

• MLL5-L complex
• phosphatase-1 (PP1)
• PTW/PP1 phosphatase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5501
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5501
• OMIM: https://mirror.omim.org/entry/176914
• UniProt: http://www.uniprot.org/uniprot/P36873.html