DNA-binding protein Ikaros; Ikaros family zinc finger protein 1; lymphoid transcription factor LyF-1 (IKZF1, IK1, IKAROS, LYF1, ZNFN1A1)

Function

• binds & activates enhancer (delta-A element) of the CD3-delta gene
• role in specification & maturation of T-lymphocytes
• interacts with a control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B-cell & T-cell development
• interacts with IKZF4 & IKZF5

Structure

• belongs to the Ikaros C2H2-type Zn+2-finger protein family
• contains 6 C2H2-type Zn+2 fingers

Compartment

nucleus

Alternative splicing

named isoforms=7

Expression

• expressed in thymus, spleen, peripheral blood Leukocytes & lymph nodes > bone marrow & small intestine

More general terms

• ikaros family zinc finger protein
• transcription factor (TF)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1032
• OMIM: https://mirror.omim.org/entry/603023
• UniProt: http://www.uniprot.org/uniprot/Q13422.html