zinc finger protein Eos; Ikaros family Zn+2 finger protein 4 (IKZF4, KIAA1782, ZNFN1A4, zinc finger protein-1A-4 )
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Function
- DNA-binding protein
- binds to the 5'GGGAATRCC-3' Ikaros-binding sequence
- transcriptional repressor
- interacts with SPI1 & MITF to repress transcription of the CTSK & ACP5 promoters via recruitment of corepressors SIN3A & CTBP2
- may be involved in the development of central & peripheral nervous systems
- self-associates & interacts with other family members IKZF1, IKZF2, IKZF3 & IKZF5
- interacts with CTBP2, SPI1 & MITF
Structure
- N-terminal zinc fingers are involved in sequence- specific DNA binding & heterotypic associations with other family members
- C-terminal zinc fingers mediate homodimerization
- belongs to the Ikaros C2H2-type zinc-finger protein family
- contains 6 C2H2-type zinc fingers
Compartment
Alternative splicing
named isoforms=2
Expression
- highly expressed in skeletal muscle
- low levels of expression in heart, thymus, kidney, liver, & spleen
- expressed in the hematopoietic cell lines MOLT-4, NALM-6 & K562
- highly expressed in THP-1 & Mo7e-IL3 cell lines, which have characteristics of myeloid & early megakaryocytic cells, respectively
Notes
'Eos' is a Greek word for rising sun