zinc finger protein Aiolos; Ikaros family zinc finger protein 3 (IKZF3, ZNFN1A3)

Function

• transcription factor
• role in regulation of lymphocyte differentiation
• interacts with IKZF4 & IKZF5
• in T cell nuclei, ikaros & aiolos mostly associates with a chromatin remodeling complex that also includes ATPase Mi2, histone deacetylases & other components of the NURD complex
• smaller amounts associate with SWI/SNF complexes

Structure

• belongs to the Ikaros C2H2-type Zn+2-finger protein family
• contains 6 C2H2-type Zn+2 fingers

Compartment

nucleus (probable)

Alternative splicing

named isoforms=6

Expression

• expressed most strongly in peripheral blood leukocytes, spleen, & thymus

More general terms

• ikaros family zinc finger protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/606221
• UniProt: http://www.uniprot.org/uniprot/Q9UKT9.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22806