Spermatogenic leucine zipper protein 1 (testis-specific protein 1, testis-specific protein NYD-TSP1, SPZ1, TSP1)

Function

• transcription factor that binds to the DNA sequence 5'-CANNTG-3'(E box) & the G-box motif
• role in regulation of cell proliferation & differentiation during spermatogenesis
• interacts with PPP1CC isoform gamma-2
• phosphorylated by ERK1 & ERK2

Structure

• contains 1 basic helix-loop-helix (bHLH) domain

Compartment

cytoplasm, nucleus

Alternative splicing

named isoforms=2

Expression

• specifically & strongly expressed in testis

Pathology

• expressed in several tumor cell lines

More general terms

• testis-specific protein
• phosphoprotein
• basic helix loop helix (bHLH) family transcription factor

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BXG8.html