protein phosphatase 1 regulatory subunit 15B (PPP1R15B)

Function

• maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1
• part of a complex containing PPP1R15B, PP1 & NCK1/2
• interacts with PP1

Structure

belongs to the PPP1R15 family

Notes

• phosphatase activity of the PPP1R15B-PP1 complex toward EIF2S1 is specifically inhibited by salubrinal, a drug that protects cells from endoplasmic reticulum stress

More general terms

• protein phosphatase-1 regulatory subunit

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84919
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84919
• OMIM: https://mirror.omim.org/entry/613257
• UniProt: http://www.uniprot.org/uniprot/Q5SWA1.html