cytoplasmic protein NCK1; NCK adaptor protein 1; Nck-1; SH2/SH3 adaptor protein NCK-alpha (NCK1 NCK)

Function

• Nck adaptor protein
• associates with Tyr-phosphorylated growth factor receptors or their cellular substrates
• maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1
• phosphorylated on Ser & Tyr residues
• associates with BLNK, PLCG1, VAV1 & NCK1 (B-cell antigen receptor-dependent)
• interacts with SOCS7
• part of a complex containing PPP1R15B, PP1 & NCK1
• interacts with RALGPS1
• may interact with phosphorylated IRS-1
• binding via SH2 domain to Tyr-phosphate (Tyr-751) of PDGF receptor-beta

Structure

• contains 1 SH2 domain
• contains 3 SH3 domains

Compartment

cytoplasm, endoplasmic reticulum

More general terms

• nck adaptor protein

Additional terms

• Nck-associated protein (NAP)

Database

• UniProt: http://www.uniprot.org/uniprot/P16333.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4690
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4690
• OMIM: https://mirror.omim.org/entry/600508