suppressor of cytokine signaling 7; SOCS-7; Nck, Ash & phospholipase C gamma-binding protein; Nck-associated protein 4; NAP-4 (SOCS7 NAP4 SOCS6)
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Function
- regulates signaling cascades probably through protein ubiquitination &/or sequestration
- role in insulin signaling & glucose homeostasis through IRS1 ubiquitination & subsequent proteasomal degradation
- inhibits prolactin, growth hormone & leptin signaling by preventing STAT3 & STAT5 activation, sequestering them in the cytoplasm & reducing their binding to DNA
- may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination & subsequent proteasomal degradation of target proteins (putative)
- protein modification; protein ubiquitination
- interacts with phosphorylated IRS4 & PIK3R1
- interacts, via the third proline-rich region, with the second SH3 domain of the adapter protein NCK1
- also interacts with GRB2, INSR, IRS1, PLCG1, SORBS3/vinexin, & phosphorylated STAT3 & STAT5
- interacts with SEPT6
Structure
- the SOCS box domain mediates the interaction with the elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (putative)
- required for IRS1 ubiquitination & subsequent proteasomal degradation
- contains 1 SH2 domain
- contains 1 SOCS box domain
Compartment
- cytoplasm
- cell membrane, cytoplasmic side
- nucleus
- mostly cytoplasmic, but shuttles between the cytoplasm & the nucleus
- rapidly relocalizes to the nucleus after UV irradiation
- cytoplasmic location depends upon SEPT7 presence
Alternative splicing
named isoforms=2
Expression
- expressed in brain & leukocytes
- also expressed in fetal lung fibroblasts & fetal brain
- induced by IL6, prolactin & growth hormone