signal transducer & activator of transcription 5A (STAT5A, STAT5)
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Function
- dual function:
- signal transduction
- activation of transcription
- binds to the GAS element & activates PRL-induced transcription
- activated by prolactin
- binds to sheep (& perhaps human) casein gene promoter
- forms a homodimer or a heterodimer with a related family member
- binds NR3C1 (putative)
- interacts with NCOA1 & SOCS7
- Tyr phosphorylated in response to IL-2, IL-3, IL-7, IL-15, GM-CSF, growth hormone, prolactin, erythropoietin & thrombopoietin
- Tyr phosphorylation is required for DNA-binding activity & dimerization
- Ser phosphorylation is also required for maximal transcriptional activity (putative)
Structure
- belongs to the transcription factor STAT family
- contains 1 SH2 domain
Compartment
- cytoplasm, nucleus
- translocated into nucleus in response to phosphorylation
More general terms
References
- ↑ Darnell JE Jr, Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science. 1994 Jun 3;264(5164):1415-21. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8197455
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6776
- ↑ Wikipedia; Note: STAT5 entry http://en.wikipedia.org/wiki/STAT5
- ↑ UniProt http://www.uniprot.org/uniprot/P42229.html