signal transducer & activator of transcription (STAT)
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Function
- the STAT proteins are the target of Janus kinases
- upon phosphorylation, the STAT proteins dimerize through SH2-pTyr interactions & translocate to the nucleus where they bind to specific promoter elements & induce gene expression[2]
- intramolecular SH2-pTyr interactions are precluded from steric considerations
- recruitment of STATs to the cytoplasmic face of the plasma membrane is facilitated by specific pTyr-SH2 interactions on the signal-transducing receptor & STAT, respectively
- JAKs associated with the activated receptors may then indiscriminatly phosphorylate STATs
More general terms
More specific terms
- signal transducer & activator of transcription-1 (STAT1, interferon-gamma activated factor, gamma-activated factor)
- signal transducer & activator of transcription 3; acute-phase response factor (STAT3, APRF)
- signal transducer & activator of transcription 4 (STAT4)
- signal transducer & activator of transcription 5A (STAT5A, STAT5)
- signal transducer & activator of transcription 5B (STAT5B)
- signal transducer & activator of transcription 6; IL-4 Stat (STAT6)
- signal transducer & activator of transcription-2 (STAT2)
Additional terms
References
- ↑ Ihle JN et al Signaling by the cytokine receptor superfamily: JAKs and STATs TIBS 19:222 1994 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8048164
- ↑ 2.0 2.1 Pawson T Protein modules and signalling networks Nature 373:573 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7531822