signal transducer & activator of transcription-2 (STAT2)

Function

• signal transducer & activator of transcription
• mediates signaling by IFN type-1 (IFN-alpha & IFN-beta) following IFN type-1 binding to cell surface receptors, Jak kinases (TYK2 & JAK1) are activated, leading to Tyr phosphorylation of STAT1 & STAT2
• the phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus
• ISGF3 binds to the IFN stimulated response element (ISRE) to activate transcription of interferon stimulated genes, which drive the cell in an antiviral state
• interacts with ISGF3G/IRF-9 in the cytoplasm
• heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation
• interacts with CRSP2 & CRSP6
• interacts with Simian virus 5 protein V & rabies virus phosphoprotein
• Tyr phosphorylated in response to IFN-alpha

Structure

• belongs to the transcription factor STAT family
• contains 1 SH2 domain

Compartment

• cytoplasm, nucleus
• translocated into the nucleus upon activation by IFN-alpha/beta

Alternative splicing

named isoforms=2

More general terms

• signal transducer & activator of transcription (STAT)

Component of

• interferon-stimulated gene factor-3

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6773
• OMIM: https://mirror.omim.org/entry/600556
• UniProt: http://www.uniprot.org/uniprot/P52630.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6773