interferon regulatory factor 9; IRF-9; IFN-alpha-responsive transcription factor subunit; ISGF3 p48 subunit; interferon-stimulated gene factor 3 gamma; ISGF-3 gamma; transcriptional regulator ISGF3 subunit gamma (IRF9, ISGF3G)

Function

• transcription regulatory factor
• mediates signaling by IFN type-1 (IFN-alpha & IFN-beta)
• following IFN type-1 binding to cell surface receptors, Jak kinases (TYK2 & JAK1) are activated, leading to Tyr phosphorylation of STAT1 & STAT2
• the phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus
• ISGF3 binds to the IFN-stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state
• interacts with STAT2 in the cytoplasm
• forms a complex with heterodimer STAT1/STAT2

Structure

• belongs to the IRF family
• contains 1 tryptophan pentad repeat DNA-binding domain

Compartment

• cytoplasm. nucleus
• translocated into the nucleus upon activation by IFN-alpha/beta

Expression

induced by IFN-alpha & IFN-beta

More general terms

• DNA-binding protein
• protein subunit
• transcription factor (TF)

Component of

• interferon-stimulated gene factor-3

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10379
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10379
• OMIM: https://mirror.omim.org/entry/147574
• UniProt: http://www.uniprot.org/uniprot/Q00978.html