tyrosine kinase TYK2 (TYK2)
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Function
- probable role in initiation of type 1 IFN signaling
- phosphorylates IFN-alpha/beta receptor alpha chain
- phosphorylates Tyr on 113, 91, & 84 kD proteins of the IFN-induced ISGF3-alpha transcription factor
- interacts with Janus kinase & microtubule-interacting protein 1 (JAKMIP1)
Structure
- belongs to the Tyr protein kinase family, JAK subfamily
- contains 1 FERM domain
- contains 1 protein kinase domain
- contains 1 SH2 domain
Expression
- observed in all cell lines analyzed
- expressed in a variety of lymphoid & non-lymphoid cell lines
Pathology
- causes excess tau production
Pharmacology
- TKY2 inhibitor deucravacitinib (Sotyktu) FDA-approved for treatment of moderate to severe plaque psoriasis
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P29597.html
- ↑ Ihle JN et al Signaling by the cytokine receptor superfamily: JAKs and STATs TIBS 19:222 1994 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8048164
- ↑ Kim J, Tadros B, Liang YH et al TYK2 regulates tau levels, phosphorylation and aggregation in a tauopathy mouse model. Nat Neurosci. 2024 Dec;27(12):2417-2429. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39528671 PMCID: PMC11614740 Free PMC article.