deucravacitinib (Sotyktu)

Indications

• moderate to severe plaque psoriasis

Contraindications

• avoid use with live virus vaccines

Dosage

• 6 mg PO QD

Monitor

• serum triglycerides baseline & periodically
• liver function tests baseline & periodically

Adverse effects

• hypersensitivity reactions
• infactions including tuberculosis
• lymphomas
• elevated serum creatine kinase & rhabdomyolysis
• hypertriglyceridemia
• elevated serum ALT, serum AST

• drug adverse effects of tyrosine kinase inhibitor(s)
• drug adverse effects of janus kinase inhibitors

Mechanism of action

• tyrosine kinase-2 inhibitor (TYK2 inhibitor) thar inhibits signaling of IL-23, IL-12, & IFN-1, cytokines involved in the pathogenesis of autoimmune diseases

More general terms

• Janus kinase inhibitor; JAK inhibitor
• dermatologic agent