Janus kinase inhibitor; JAK inhibitor
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Indications
- rheumatoid arthritis
- psoriatic arthritis
- plaque psoriasis
- ulcerative colitis
- juvenile idiopathic arthritis
- ankylosing spondylitis
Adverse effects
- increased all-cause mortality, including sudden cardiovascular death
- majoradverse cardiovascular events
- thrombosis, deep venous thrombosis, pulmonary embolism[2]
- malignancies (excluding non-melanoma skin cancer)
- risks of serious heart-related events, cancer, blood clots, & death
- drug adverse effects of tyrosine kinase inhibitor(s)
- drug adverse effects of janus kinase inhibitors
Mechanism of action
- inhibitors of Janus kinase
- current Janus kinase inhibitors are also small inhibitory antineoplastic agents
More general terms
More specific terms
- baricitinib (Olumiant)
- delgocitinib
- deucravacitinib (Sotyktu)
- deuruxolitinib (Leqselvi)
- ilunocitinib (Zenrelia)
- momelotinib (Ojjaara)
- ritlecitinib (Litfulo)
- tofacitinib (Xeljanz)
- upadacitinib (Rinvoq, ABT-494)
Additional terms
References
- ↑ FDA MedWatch. Safety Information. Sept 1, 2021 Janus Kinase (JAK) inhibitors: Drug Safety Communication - FDA Requires Warnings about Increased Risk of Serious Heart-related Events, Cancer, Blood Clots, and Death. https://www.fda.gov/safety/medical-product-safety-information/janus-kinase-jak-inhibitors-drug-safety-communication-fda-requires-warnings-about-increased-risk
- ↑ 2.0 2.1 Harris S JAK Inhibitors Increased VTE Risk in People With Inflammatory Disease Link appears to be soft, but caution advised for higher-risk patients who use agents for extended periods. MedPage Today December 30, 2022 https://www.medpagetoday.com/reading-room/acrr/psoriaticarthritis/102442
Maqsood MH, Weber BN, Haberman RH et al Cardiovascular and Venous Thromboembolic Risk With Janus Kinase Inhibitors in Immune-Mediated Inflammatory Diseases: A Systematic Review and Meta-Analysis of Randomized Trials. ACR Open Rheumatol. 2022 Oct;4(10):912-922 PMID: https://www.ncbi.nlm.nih.gov/pubmed/35903881 PMCID: PMC9555201 Free PMC article https://onlinelibrary.wiley.com/doi/full/10.1002/acr2.11479