ritlecitinib (Litfulo)

Indications

• treatment of alopecia areata in adults & adolecents >= 12 years

Contraindications

• use in combination with other JAK inhibitors, immunosuppressants, cyclosporine, biologic immunmodulators
• rheumatoid arthritis (highe mortality vs TNF-alpha inhibitor)

Dosage

• 50 mg orally once daily.

Adverse effects

• venous thromboembolism
  • pulmonary embolism
• arterial thromboembolism
• headache, diarrhea, acne, rash, urticaria, folliculitis, pyrexia
• atopic dermatitis, dizziness, increased serum creatine phosphokinase, herpes zoster, anemia, stomatitis

* Warnings:

• serious infection, malignancy, major cardiovascular events, thrombosis, death

• drug adverse effects of tyrosine kinase inhibitor(s)
• drug adverse effects of janus kinase inhibitors

More general terms

• Janus kinase inhibitor; JAK inhibitor

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=118115473
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=118116220