mediator of RNA polymerase II transcription subunit 17; activator-recruited cofactor 77 kD component; ARC77; cofactor required for Sp1 transcriptional activation subunit 6; CRSP complex subunit 6; mediator complex subunit 17; thyroid hormone receptor-associated protein complex 80 kD component; trap80; transcriptional coactivator CRSP77; vitamin D3 receptor-interacting protein complex 80 kD component; DRIP80 (MED17, ARC77, CRSP6, DRIP77, DRIP80, TRAP80)

Function

• component of the mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase 2- dependent genes
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with GATA1 & PPARG (putative)
• interacts with STAT2

Structure

• belongs to the mediator complex subunit 17 family

Compartment

nucleus (probable)

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• transcription factor (TF)
• phosphoprotein

Component of

• thyroid hormone receptor associated protein complex (TRAP)
• activator-recruited cofactor (ARC)/DRIP
• CRSP complex
• mediator complex (mediator of RNA polymerase 2 transcription)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9440
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9440
• OMIM: https://mirror.omim.org/entry/603810
• UniProt: http://www.uniprot.org/uniprot/Q9NVC6.html