GATA binding factor-1; erythroid transcription factor GATA-1 (ERYF1, GF-1, NF-E1, GATA1)

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Function

Structure

  • the 2 fingers are functionally distinct & cooperate to achieve specific, stable DNA binding
  • the 1st finger is necessary only for full specificity & stability of binding,
  • the 2nd one is required for binding (putative)
  • contains 2 GATA-type Zn+2 fingers

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

erythrocytes

Pathology

Laboratory

More general terms

References

  1. Andrews NC, Erdjument-Bromage H, Davidson MB, Tempst P, Orkin SH. Erythroid transcription factor NF-E2 is a haematopoietic- specific basic-leucine zipper protein. Nature. 1993 Apr 22;362(6422):722-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8469283
  2. 2.0 2.1 Weiss MJ, Orkin SH. Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis. Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9623-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7568185
  3. Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/GATA1ID40689chXp11.html
  4. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=GATA1
  5. UniProt http://www.uniprot.org/uniprot/P15976.html

Database