GATA binding factor-1; erythroid transcription factor GATA-1 (ERYF1, GF-1, NF-E1, GATA1)
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Function
- transcriptional activator
- probably serves as a general switch factor for erythroid development
- regulate genes that define the erythroid phenotype
- supports viability of erythroid precursors by preventing apoptosis[2]
- binds to DNA sites with consensus sequence [AT]GATA[AG] 'GATA' sequences within regulatory regions of globin genes & of other genes expressed in erythroid cells
- N-terminal Zn+2 finger interacts with ZFPM1/FOG1 interacts with GFI1B
Structure
- the 2 fingers are functionally distinct & cooperate to achieve specific, stable DNA binding
- the 1st finger is necessary only for full specificity & stability of binding,
- the 2nd one is required for binding (putative)
- contains 2 GATA-type Zn+2 fingers
Compartment
Alternative splicing
named isoforms=2
Expression
Pathology
- defects in GATA1 are the cause of:
Laboratory
More general terms
References
- ↑ Andrews NC, Erdjument-Bromage H, Davidson MB, Tempst P, Orkin SH. Erythroid transcription factor NF-E2 is a haematopoietic- specific basic-leucine zipper protein. Nature. 1993 Apr 22;362(6422):722-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8469283
- ↑ 2.0 2.1 Weiss MJ, Orkin SH. Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis. Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9623-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7568185
- ↑ Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/GATA1ID40689chXp11.html
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=GATA1
- ↑ UniProt http://www.uniprot.org/uniprot/P15976.html