mediator of RNA polymerase II transcription subunit 14; activator-recruited cofactor 150 kD component; ARC150; cofactor required for Sp1 transcriptional activation subunit 2; CRSP complex subunit 2; mediator complex subunit 14; RGR1 homolog; hRGR1; thyroid hormone receptor-associated protein complex 170 kD component; trap170; transcriptional coactivator CRSP150; vitamin D3 receptor-interacting protein complex 150 kD component; DRIP150 (MED14, ARC150, CRSP2, CXorf4, DRIP150, EXLM1, RGR1, TRAP170)

Function

• component of the mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase 2- dependent genes
• interacts with GATA1 (putative)
• interacts with AR, ESR1, SREBF1 & STAT2

Structure

• belongs to the mediator complex subunit 14 family

Compartment

nucleus (probable)

Expression

ubiquitous

More general terms

• transcription factor (TF)
• phosphoprotein

Component of

• activator-recruited cofactor (ARC)/DRIP
• mediator complex (mediator of RNA polymerase 2 transcription)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9282
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9282
• OMIM: https://mirror.omim.org/entry/300182
• UniProt: http://www.uniprot.org/uniprot/O60244.html