signal transducer & activator of transcription 6; IL-4 Stat (STAT6)

Function

• dual function:
  • signal transduction
  • activation of transcription
• involved in interleukin-4 signalling
• forms a homodimer or a heterodimer with a related family member (putative)
• interacts with NCOA1 via its C-terminal LXXLL motif
• Tyr phosphorylated following stimulation by IL-4 & IL-3 (putative)

Structure

• belongs to the transcription factor STAT family
• contains 1 SH2 domain

Compartment

• cytoplasm, nucleus
• translocated into the nucleus in response to phosphorylation

Alternative splicing

named isoforms=2

More general terms

• signal transducer & activator of transcription (STAT)

Database

• UniProt: http://www.uniprot.org/uniprot/P42226.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6778
• OMIM: https://mirror.omim.org/entry/601512
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6778