signal transducer & activator of transcription 5B (STAT5B)

Function

• dual function:
  • signal transduction
  • activation of transcription
• binds to GAS element & activates PRL-induced transcription
• forms a homodimer or a heterodimer with a related family member
• binds NR3C1 (putative)
• interacts with NCOA1, NMI & SOCS7
• Tyr phosphorylated (putative)

Structure

• belongs to the transcription factor STAT family
• contains 1 SH2 domain

Compartment

• cytoplasm (putative), nucleus
• translocated into the nucleus in response to phosphorylation (putative)

Pathology

• defects in STAT5B are the cause of Laron-type dwarfism-2

More general terms

• signal transducer & activator of transcription (STAT)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6777
• OMIM: https://mirror.omim.org/entry/245590
• OMIM: https://mirror.omim.org/entry/604260
• UniProt: http://www.uniprot.org/uniprot/P51692.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6777