thrombopoietin; megakaryocyte colony stimulating factor; C-MPL ligand; megakaryocyte growth & development factor (MGDF, THPO)

Function

• cytokine that regulates megakaryocyte development
  • acts at a late stage of megakaryocyte development
  • may be the major physiological regulator of circulating platelets
• ligand for Mpl receptor

Structure

• two-domain structure with an erythropoietin-like N-terminal & a Ser/Pro/Thr-rich C-terminal
• belongs to the EPO/TPO family
• at least two forms, 25 kDa & 31 kDa

Compartment

secreted

Alternative splicing

named isoforms=3

Pathology

• defects in THPO are a cause of essential thrombocythemia

Pharmacology

• avatrombopag (Doptelet) is a thrombopoietin receptor agonist that stimulates platelet production

Laboratory

• thrombopoietin in plasma

Comparative biology

• cDNAs for human, dog & mouse predict proteins of 353, 352 & 356 amino acids respectively.

More general terms

• thrombopoietin receptor agonist
• cytokine
• glycoprotein

Additional terms

• megakaryocyte
• thrombopoietin receptor; TPO-R; myeloproliferative leukemia protein; C-mpl; CD110 (MPL, TPOR)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7066
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7066
• OMIM: https://mirror.omim.org/entry/187950
• OMIM: https://mirror.omim.org/entry/600044
• UniProt: http://www.uniprot.org/uniprot/P40225.html